The real number of medications has been declining since 2009. ‘Our objective was to examine historic trends to help realize why Alzheimer’s disease treatment development efforts so often fail,’ said Jeffrey L. Cummings, M.D., ScD, Director of the Cleveland Clinic Lou Ruvo Center for Brain Wellness. ‘With an estimated 44 million people living worldwide with the problem, the study implies that the Alzheimer’s disease drug development ecosystem needs more support provided the magnitude of the problem.’ Using the advanced search mechanisms of ClinicalTrials.gov, a national government website that records most ongoing clinical trials, Dr.Also called Edwards syndrome, Trisomy 18 occurs whenever a person exists with three copies of the 18th chromosome, instead of two. That extra chromosome inhibits typical childhood advancement, causing children to become born with clenched hands, crossed hip and legs, foot with rounded bottoms, a little jaw and head, and intellectual disabilities. The disorder could cause serious heart and kidney problems also. Trisomy 18 takes place in about one from every 3,000 births. It really is three times more prevalent in girls than males, based on the National Institutes of Wellness. Unlike Down syndrome, which is usually caused by a supplementary chromosome 21, the problems due to Trisomy 18 are connected with even more life-threatening medical problems and 50 % of babies with Trisomy 18 who are carried to term are stillborn, based on the Trisomy 18 Foundation.